Januzzi et al. demonstrated that NT-proBNP at the time of presentation was not only diagnostically useful, but also strongly predicted likelihood for short-term mortality in subjects with CHF, with a more than five-fold increase in risk for death by 76 days among those with marked elevation in NT-proBNP concentrations (Januzzi et al. 2006). Here, NPPB is linked to congestive heart failure.