Like in acute coronary syndrome (Morrow et al. 2005), studies have suggested that BNP or NT-pro-BNP (as cardiac Troponin) were accurate in risk stratification for PE in a middle-aged population and had a high positive predictive value for in-hospital death (Binder et al. 2005; Pieralli et al. 2006; Logeart et al. 2007). This evidence concerns the gene NPPB and acute coronary syndrome.