Initial data suggestive of a potential role of CRP as an independent predictor of cardiac events came from the European Concerted Action on Thrombosis and Disabilities (ECAT) study (Anonymous, 1993) that established elevated CRP levels as a predictor for future coronary events in people with stable and unstable angina (Haverkate and others, 1997). This evidence concerns the gene CRP and Venous thrombosis.