An investigation involving the Augsburg cohort of the Monitoring Trends and Determinants in Cardiovascular Disease (MONICA) study (Bothig, 1989) evaluated the role of CRP in cardiovascular risk prediction in initially healthy men on the basis of an 8-year follow-up, and confirmed the predictive relevance of serum CRP levels for occurrence of coronary heart disease in subjects without prior cardiac disease (Koenig and others, 1999). The gene discussed is CRP; the disease is coronary artery disorder.