Discussing the clinical consequences of elevated 3-nitrotyrosine levels, Shishehbor and colleagues embarked on a case-control study to evaluate its predictive power for the presence of CVD, and found, after adjustment for the Framingham criteria and plasma CRP levels, a significantly higher odds ratio for coronary heart disease in the upper quartiles of 3-nitrotyrosine levels compared to the lowest quartile (Shishehbor and others, 2003). This evidence concerns the gene CRP and coronary artery disorder.