Notably, DU4475, a human breast cancer cell line derived from a recurrent thoracic wall tumor following mastectomy due to a poorly differentiated invasive ductal carcinoma [19], carries a nonsense mutation at codon 1577 of the APC gene, only 5 residues downstream of the targeted Apc1572T allele [20],[21]. This evidence concerns the gene APC and invasive ductal breast carcinoma.