Splice variation and significant post-translational modifications result in a multifunctional group of CD44 adhesion molecules, with important functions in embryogenesis, lymphocyte activation and homing, angiogenesis, leukocyte extravasation, anti-apoptosis signalling, presentation of growth factors and proteases, and cell migration and proliferation, including during tumor metastasis [30,52-60]. Here, CD44 is linked to neoplasm.