NFKB1 and rheumatoid arthritis: The anti-inflammatory effects of triptolide include the inhibition of IL-2 production in mouse T cell hybridomas, inhibition of transcriptional activation of NF-κB, suppression of NF-κB in T lymphocytes [12] and reduction of PGE2 production in human monocytes and RA synovial fibroblasts [13].