Bisulphite sequencing of up to 12 individual alleles from 9 leukaemia cell lines, 6 B-ALL, 6 T-ALL, 1 pre-B-ALL, 6 normal blood and 1 normal bone marrow sample confirmed leukaemia-specific methylation across the entire RASSF6 CpG island in cell lines, B-ALL and T-ALL (figure 1C, and Additional file 1; figure S3 and Additional file 2; table S1). Here, RASSF6 is linked to acute lymphoblastic leukemia.