Based on a mean DFS of 99 months (95% CI: 90–107 months) patients without DKK3 methylation in the tumor revealed longer mean DFS (110 months, 95% CI: 99–122 months) than patients with DKK3 methylation in the tumor (86 months, 95% CI: 75–97 months). Here, DKK3 is linked to neoplasm.