Based on a mean OS of 141 months (95% CI: 127–154 months) patients without DKK3 methylation in the tumor tissue revealed much longer mean OS (170 months, 95% CI: 163–177 months) than patients with DKK3 methylation in the tumor tissue (113 months, 95% CI: 95–131 months). This evidence concerns the gene DKK3 and neoplasm.