Furthermore, in murine cells it was shown that the HN878 PGL was critical in the regulation of TNF, IL-6, and MCP-1 since deletion of the PGL in the HN878 mutant (HN878 pks1-15::hyg) resulted in higher levels of these factors, which was associated with enhanced survival of TB infected mice [20]. This evidence concerns the gene ARAFP2 and tuberculosis.