UCP2 and malignant colon neoplasm: In an attempt to reveal the underlying molecular mechanisms, Derdak et al. overexpressed UCP2 in human colon cancer cells and showed that it was accompanied by reduced ΔΨ and ROS production and increased oxygen consumption, these changes being associated with inactivation of tumor suppressor p53 through its NH2-terminal phosphorylation and induction of the glycolytic phenotype [304].