DNAJC3 and ischemia: Thus, the present observation of METH-induced Dnajc3/p58IPK does suggest its participation in a coordinated response to attenuate or prevent METH-mediated deleterious effects on the ER in conjunction with VEGF which has been shown to protect neurons against ischemia [41], [69] glutamate toxicity [70] and ER stress [43].