These findings suggest that HIF-1α/VHL may play a significant role in regulating the expression of CXCR4 on tumor cells, and further understanding this molecular mechanistic link between HIF-1α and CXCR4 expression may allow the discovery of a novel means to intervene and impact on reducing metastatic NSCLC. This evidence concerns the gene CXCR4 and non-small cell lung carcinoma.