Our findings suggest that SNPs of the XRCC1 gene at codon 399 influences the response of cervical carcinoma to platinum-based neoadjuvant chemotherapy, and that the genotype carrying at least one Gln allele may be considered to be a candidate molecular marker to predict poor response to NAC in locally advanced cervical carcinoma. The gene discussed is XRCC1; the disease is cervical carcinoma.