In addition, we found that this altered expression of the XRCC1 protein was associated with XRCC1 genotype variation at codon 399, the protein expression was significantly higher in the patients with a Gln allele (Arg/Gln or Gln/Gln) than that with the Arg/Arg genotype in locally advanced cervical carcinoma. Here, XRCC1 is linked to cervical carcinoma.