PLOD1 and polycystic ovary syndrome: Tonic LH secretion in the follicular phase affects oocytes by the early resumption of meiosis and premature oocyte maturation with ovulation of the prematurely mature egg will result in either an inability to be fertilized or a miscarriage if fertilization occurs.[8] Balen et al. reported that PCOS had a miscarriage rate of 36% when compared with 24% in women with normal ovaries, which is also consistent with our findings wherein 35/75 who aborted, were found to have elevated LH levels.[9]