Interestingly, the most common PTGER3 haplotype ATAAA (rs2206344, rs3765894, SNP_A-4228934, rs2744918, rs2268062) was associated with the risk for hypertension (P = 1.6×10−5, OR = 1.50; hypertensives 57%; normotensives 46%), whereas two other prevalent variants exhibit a protective effect (Figure 6B). This evidence concerns the gene PTGER3 and hypertensive disorder.