After subdivision of study samples based on BMI, the association of rs11195419 (ADRA2A) with hypertension was detected only in the overweight group (KORA S3: P = 5.21×10−2, OR = 1.37; Replication: P = 4.48×10−2, OR = 1.17; Meta-analysis: P = 8.0×10−3, OR = 1.20) and the individuals with normal weight were not affected (P = 0.78) (Figure 4,Table 3). This evidence concerns the gene ADRA2A and Hypertension.