In the subsequent early subacute phase (> 3 days after onset of hemorrhage), the transformation of intracellular deoxyhemoglobin to methemoglobin is known to induce a change of the MR-signal to high intensities on T1WI and low intensities on T2WI images, whereas in the late subacute phase (> 7 days post hemorrhage), the occurrence of extracellular methemoglobin results in high signals in both T1WI and T2WI, which contrasts much better with the native tumor and liver parenchymal signal. This evidence concerns the gene HBG2 and neoplasm.