Sorafenib hits tumor cells on multiple levels such as the Raf/MEK/ERK signalling pathway, as well as angiogenesis by targeting vascular endothelial growth factor receptors-1/-2/-3 (VEGFR-1/-2/-3) or platelet derived growth factor receptor beta (PDGFR-β) tyrosine kinases [7-9]. The gene discussed is PDGFRB; the disease is neoplasm.