Activation of glycolysis in human lung cancers and cancer cells was inferred from an up-regulation of glycolysis-related enzymes such as hexokinase II (HK II), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and the bifunctional regulatory enzyme phosphofructokinase 2 (PFK-2) [2-7]. The gene discussed is GAPDH; the disease is lung carcinoma.