For Krebs cycle DH, there was a substantial decrease of isocitrate DH (IDH) and α-ketoglutarate DH (OGDH) in contrast to a modest activation of malate DH (MDH) expression, while succinate DH (SDH) and fumarate hydratase (FH) showed no statistically significant changes in expression in tumor tissues. Here, MDH2 is linked to neoplasm.