Following up on a linkage signal in the CHOP region of chromosome 12q13.1 in Italian T2D families, we have previously shown that CHOP 5'UTR-c.279T>C and +nt30C>T haplotype variants are associated with early-onset T2D under a recessive and additive model [7]. Here, DDIT3 is linked to type 2 diabetes mellitus.