INS and obesity due to melanocortin 4 receptor deficiency: Furthermore, the consistency in i) the observed secular detrimental changes for all the considered cardiometabolic CVD-RF (e.g. HDL-cholesterol, triglyceride, glucose, insulin) and ii) the good concordance between the proportionate changes in the prevalence of obesity and the proportionate changes in the mean levels of the considered cardiometabolic CVD-RF in men vs. women, suggests coherence in the results.