CDH1 and clear cell renal carcinoma: In our dataset, concomitant loss of differentiation and acquisition of “wound healing” was associated with features of EMT including down regulation of the epithelial marker CDH1 and up regulation of the mesenchymal markers FN1 and VIM (for detailed information see Supplemental file S5 and S6), suggesting that EMT may play a role in clear cell renal cell carcinoma progression.