In comparison, TNF-α−/−[25],[28], MyD88−/−[8], IL-12−/−[10] or IFN-γ−/−[11] C57BL/6 mice, normally thought of as highly susceptible mice, display necrotic lesions only after 4 or 6 weeks of infection and mutilation is observed only after 8–10 weeks. Here, TNF is linked to infection.