As for RCC, homozygotes for the “high-risk” MMP1 allele (rs1799750, c.-1607 2G) had an earlier age at diagnosis of retinal angioma and cerebellar haemangioblastoma than patients homozygous for the “low risk” MMP1 allele (rs1799750, c.-1607 1G) (Fig 2B and 2C) and homozygotes for the p.45Glu MMP3 allele (rs679620 c.198G) had earlier age at diagnosis of retinal angioma and cerebellar haemangioblastoma than those homozygous for the p.45Lys MMP3 allele (rs679620 c.198A (see Fig 1B and Fig 1C). Here, MMP3 is linked to renal cell carcinoma.