For the MMP1 rs1799750 polymorphic variant, the “high-risk” MMP1 allele (c.-1607 2G, that was associated with an earlier onset of RCC in VHL patients) was significantly increased in the Polish sporadic RCC patients compared to controls (p = 0.049 OR 1.25, 95%CI 1.003–1.55)(See Table 1). The gene discussed is VHL; the disease is renal cell carcinoma.