Thus for retinal angiomas the final model (overall χ2 = 7.04 P = 0.0296) retained MMP1 (rs1799750) and MMP3 (rs679620) (P = 0.012 and P = 0.041 respectively) and likewise, for cerebellar haemangioblastoma (overall model fit χ2 = 5.99 P = 0.0499) only MMP1 (rs1799750) and MMP3 (rs679620) were retained (P = 0.028 and P = 0.055 respectively) and CDH1 (rs16260), IGFBP3 (rs2854744), STK15 (rs2273535) and VEGF (rs1570360) were excluded. The gene discussed is IGFBP3; the disease is hemangioma of retina.