Despite positive CCHCR1 and Ki67 expression in vivo in skin cancer and in Affymetrix assay of SCC cell lines, we show that CCHCR1 and Ki67 mRNAs are downregulated in cultured cells with ascending transformation and also in non-tumorigenic HaCaT cells treated with compounds that promote tumors in vivo. Here, MKI67 is linked to skin neoplasm.