Additionally, because of the known cross-talk and functional network between FOXA1 and the regulation of ERα and its downstream targets, the expression of FOXA1 in ER-negative breast cancer patients may represent the existence of an alternative oestradiol-independent response pathway, which may allow the 5 to 15% of ER-negative tumours to become responsive to endocrine-driven therapies. The gene discussed is FOXA1; the disease is neoplasm.