Performing comparative Gene-Set Enrichment Analysis (GSEA), Aggarwal et al. [46] demonstrated that the increased expression of TCL1A was significantly associated (P < 0.05) with some of the most important pathways controlling B-cell lymphoma pathogenesis and heterogeneity, including B-cell receptor pathway. The gene discussed is TCL1A; the disease is B-cell non-Hodgkin lymphoma.