HOX gene expression was evaluated in our patient cohort: HOXA10, HOXA9, HOXA7, HOXA5 and HOXA3 were found to be generally upregulated in samples carrying MLL translocation, both in ALL and AML, while HOXA11 and HOXA6 showed common overexpression in AML/MLL+ cases [16]. The gene discussed is HOXA3; the disease is acute lymphoblastic leukemia.