A translocation-related signature was characterized by overexpression of ZEB2, SRGAP2P1, TMEM30A, AK2, TMED2, HIPK3, FAM62B and MEIS1 genes in MLL positive samples both ALL and AML, while a common upregulation of PAX5, CD72, CSRP2, LOC100130458, TCL1A and EBF1 genes correlated with ALL patients in a phenotype-related signature. The gene discussed is HIPK3; the disease is acute lymphoblastic leukemia.