GPT and liver disorder: No changes considered to be of clinical relevance were observed in regard to physical, haematological or urinalysis parameters during the initial phase; however, 1/43 (2%) patient presented with hepatic disorder of increased liver enzymes (aspartate amino transferase: 122 units/litre, alanine amino transferase: 188 units/litre and alkaline phosphatase: 635 units/litre) at a dose of 6 mg/kg per day.