Based on previous data showing that the lack of histamine production confers resistance to CM and given that H3R signaling inhibits the synthesis and the release of histamine by histaminergic neurons [5], [17], we hypothesized that the uncontrolled histamine release by histaminergic neurons, resulting from a deficiency in H3R signaling, would be detrimental to the host during malaria disease. Here, HRH3 is linked to malaria.