CRP and malaria: In order to investigate the possible involvement of CRP in innate immunity against malaria, and to further define potential immunological factors contributing to the ethnic differences in malaria susceptibility, the -717 T>C (rs2794521), -286 C>T>A (rs3091244,) +1444 C>T (rs1130864) CRP genotypes and malariometric indices were analysed in individuals of sympatric ethnic groups from two countries, Mali and Sudan, with markedly different malaria endemicity.