KIF11 and glioblastoma: Compounds 1, 3, 4, 5 and 6, which bear a positive in silico profile, were first tested for their antiproliferative effect on GBM cell-lines in an MTT proliferation assay: U87MG and DBTRG-05-MG cells were treated for 72 hours with the KIF11 kinesin inhibitors at concentrations varying from 10 nM to 200 μM, 24 h after seeding (compound 1 from 10 nM to 20 μM, compound 3, 4, 5 and 6 from 10 nM to 200 μM).