In our cohort as well as in a prior study of septic patients [9], resistin did not correlate to obesity measured by BMI in both subgroups of sepsis and non-sepsis patients which suggests that in circumstances of critical illness the release of resistin by macrophages plays a superior role compared with secretion from adipocytes. The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.