Indeed, a significant down-regulation of the co-stimulatory molecules CD80/B7.1 and CD86/B7.2 (Figure 5A and B), but not MHC class-II, (data not shown) was found ex-vivo on DCs from NPC-treated R-EAE mice, as compared to DCs from sham-treated controls. The gene discussed is CD80; the disease is nasopharyngeal carcinoma.