Mavrommatis et al [24] studied the activation of fibrinolysis in septic patients during the first day in the ICU, and observed that t-PA/PAI-1 complexes (4.7 ± 0.6 vs 2.1 ± 0.2 ng/mL) and the percentage of fibrinogen/fibrin degradation products (100 vs 57%) were higher in patients with septic shock than in those without (all p < 0.001). The gene discussed is SERPINE1; the disease is septic shock.