KRT18 and Sepsis: When comparing cytokeratin measurements in patients with sepsis and either impaired (bilirubin ≥1.2 mg/dL or 20.5 μmol/L → liver-SOFA ≥1) or preserved (bilirubin < 1.2 mg/dL or 20.5 μmol/L → liver-SOFA = 0) liver function, Figure 3 shows significantly increased levels of total CK-18 and CK-18 fragments in septic patients with an impaired liver function, in comparison with patients with sepsis and preserved liver function.