PAR1 expression was found mainly in the entire membrane although some cytoplasmatic staining was also observed (Figure 1d); we found some degree of variation in the staining of PAR1 within the tumor; although we were assaying a biopsy sample of the tumor; we have been able to assayed some tumor samples (from the surgery), initially found PAR1 positive; roughly we found more than 50% of the tumors cells were immune reactive for PAR1 staining; non significant staining was found in the surrounding tumor microenvironment. Here, F2R is linked to neoplasm.