Furthermore, mutations in Foxl2 are notably involved in three well-defined conditions that cover the entire spectrum of ovarian pathology: premature ovarian failure with and without ovarian dysgenesis in humans [25]; blockage of follicle formation with secondary partial ovary-to-testis sex reversal in mice [14,26]; and embryonic sex reversal, sometimes leading to complete XX maleness in goats [27]. The gene discussed is FOXL2; the disease is primary ovarian failure.