Therefore, the pathogenesis of HIV-1 infection can be modulated by the ICAM-1/LFA-1 interaction through modulatory effects on cell to-cell transmission of HIV-1, virus replication, virus-mediated syncytium formation, depletion of CD4 T cells, and destruction of the architecture of secondary lymphoid organs [57-62]. The gene discussed is CD4; the disease is HIV-1 infection.