In contrast, relative risks per 100 cells/μL lower CD4 increased with time after seroconversion, for both AIDS (10 studies, 14 datapoints) and death (7 studies, 8 datapoints; Table 1) (Figures 2c and 1d): from 1.0 at seroconversion to an estimated 3.0 (95% CI 2.6–3.4) by 6 years for AIDS (p<0.0001 for trend), and to 2.8 (1.9–3.7) for death (p<0.0001). The gene discussed is CD4; the disease is AIDS.