As infection progresses and worsening immune deficiency allows opportunistic infections (OI) and AIDS-defining illnesses to occur, the prognostic value of CD4 increases (Figure 3b), due to strong increases in relative prognostic risks per unit CD4 decrease (Figure 2c&d) and increasing proportional within-population variability in CD4 levels (Figure 1b). This evidence concerns the gene CD4 and osteogenesis imperfecta.