We identified a robust protein-protein interaction between LRRK2 and CHIP (C-terminus of Hsp70-Interacting Protein), which is an E3 ubiquitin ligase crucial for the ubiquitination of several heat shock protein (HSP)70/90 client proteins that are involved in neurodegenerative disease [25]. Here, LRRK2 is linked to neurodegenerative disease.