CHIP has previously been shown to promote the proteasomal degradation of other proteins implicated in neurodegenerative diseases such as tau, Aβ, α-synuclein oligomers and proteins with expanded polyglutamine repeats [34], [41], [42], [43], [44], [45], [46], [47], [48]. This evidence concerns the gene STUB1 and neurodegenerative disease.