Subsequent PMA detected a deletion of both the CHD5 and p73 genes, which lie distal to DEAR1 in Chromosome 1p, suggestive of a terminal deletion of one allele with a breakpoint within the DEAR1 promoter, which then resulted in LOH encompassing two distal candidate tumor suppressors on Chromosome 1p (Figure 3E). Here, CHD5 is linked to neoplasm.