In specimens demonstrating down-regulation of DEAR1 in DCIS transition, 5/10 specimens (50%, for which invasive carcinoma was available for analysis) showed loss or down-regulation in the adjacent invasive carcinoma (Figure 2A [iii]) with the remaining five of ten invasive lesions positive for DEAR1 staining (unpublished data). The gene discussed is TRIM62; the disease is ductal breast carcinoma in situ.