In this issue of PLoS Medicine, Ann Killary and colleagues describe the discovery and characterization of a new tumor suppressor gene, ductal epithelium–associated RING Chromosome 1 (DEAR1) [1], that maps to Chromosome 1p35.1, a region of the chromosome that is associated with loss of heterozygosity in breast and other epithelial cancers [2]. The gene discussed is TRIM62; the disease is neoplasm.