Moreover, α2M was found to co-localize with beta-amyloid (Aβ) plaques in AD patients [43], and is supposed to mediate the internalization and the clearance of α2M-Aβ complexes, possibly by interaction with one of its major neuronal receptors, the low-density lipoprotein receptor-related protein (LRP) [44], [45], [46], [47], [48]. Here, A2M is linked to Alzheimer disease.