Although numerous studies have reported associations between MGMT and survival in glioblastomas treated with alkylating agents, few reports support the findings of EORTC 26981/22981 & NCIC CE.3 in large cohorts treated with temozolomide and radiotherapy (Hegi et al, 2005; Stupp et al, 2005; Brandes et al, 2008). Here, MGMT is linked to glioblastoma.