In contrast to our findings in an orthotopic model of breast cancer where wild-type IGFBP4 had no effect on tumour growth, wild-type IGFBP4 inhibited tumour growth in non-orthotopic murine models of colon cancer and prostate cancer where transfected cells were implanted subcutaneously (Damon et al, 1998; Durai et al, 2007). Here, IGFBP4 is linked to malignant colon neoplasm.