Recently, Song et al. [33] have demonstrated that unconjugated bile acids such as deoxycholate induced CREB- and AP-1-dependent COX-2 expression in esophageal adenocarcinoma cells and in vivo rat model of bile reflux through ROS-mediated activation of PI3K/AKT and ERK1/2. This evidence concerns the gene MAPK3 and esophageal adenocarcinoma.