APOE and obesity due to melanocortin 4 receptor deficiency: Other genes are also involved in the catabolism of chylomicrons, such as those for apolipoprotein E, apolipoprotein A-V [5] and glycosylphosphatidylinositol hgih density lipoprotein-binding protein [6,7] Patients with familial forms of hypertriglyceridaemia in combination with secondary acquired disorders (obesity, diabetes, pregnancy or drugs, including estrogens, retinoids, highly-active antiretroviral drugs) account for most individuals presenting with chylomicronaemia [8].