LPL and pancreatitis: Certain polymorphisms in the apo A-V gene have been associated with triglyceride levels in a healthy population [32] and in persons with severe hypertriglyceridaemia [33,34] Indeed, severe chylomicronaemia with repeated hypertriglyceridaemic pancreatitis has been reported in two persons with apo A-V deficit [35,36] One mechanism proposed is that apo A-V lowers triglyceride concentrations by guiding VLDL and chylomicrons to proteoglycan-bound LPL for lipolysis [37] or simply acting as a cofactor of the enzyme.