Recently, the VISEP (Volume Substitution and Insulin Therapy in Severe Sepsis) trial, a multi-center randomized trial comparing IIT with conventional therapy in critically ill septic patients, was terminated early due to a lack of evidence of survival benefit with IIT and a significantly higher incidence of hypoglycemia in those allocated to IIT (17.0% vs. 4.1%, P < 0.001). The gene discussed is INS; the disease is Hypoglycemia.