These data suggest that the inhibition of leptin signaling negatively impacted tumor growth by decreasing leptin-induced expression of several factors implicated in epithelial cell proliferation, adhesion, inflammation and angiogenesis; for example, β3-integrin [38,41,42], metalloproteinases [43], leukemia inhibitory factor, leukemia inhibitory factor receptor, IL-1, IL-1 receptor (IL-1R tI), and IL-1 receptor antagonist [32,34,38-40]. This evidence concerns the gene LEP and neoplasm.