CYP19A1 and carcinoma: The multiplicative SIP score for carcinoma cells ("Proportion of aromatase immunopositivity" multiplied with "Relative intensity of aromatase immunoreactivity") was positively correlated with the aromatase enzyme activity measured by the biochemical tritiated-water release assay [32], indicating that aromatase expression in the carcinoma cells may be a predictive marker for response to AI treatment.