Because several mammalian proteins involved in the pathogenesis of neurodegenerative diseases are known to affect lipid metabolism [38], and several neuropathologies lead to changes in PEA levels in brain [39], we expressed mutant huntingtin (Htt) fragments and α-synuclein in yeast and assessed their effect on PEA production and inactivation. Here, HTT is linked to neurodegenerative disease.