Let us take the potential interaction in risk of Alzheimer's disease (AD) between the ε4 allele of apolipoprotein E (APOE4) and the GG genotype of the C/G polymorphism (rs638405) in exon 5 of the β-site APP-cleaving enzyme (BACE1) [13] (Table 1). This evidence concerns the gene BACE1 and early-onset autosomal dominant Alzheimer disease.