The median number of intra-epithelial T-helper (CD3+, CD8-), cytotoxic T lymphocyte (CTL, CD8+, CD57-) and natural killer cells (NK, CD8+/CD57+) found in 34 CRCs available for analyses were 20, 37, and 0 cells/mm2 tumour, respectively. The gene discussed is CD8A; the disease is neoplasm.