In MSI-high tumours, an active immune response by the host (represented by a high number of TILs) was also associated with a better survival, especially when associated with granzyme B positivity.[33] The group of MAP patients with a high number of CD8+ and granzyme B+ TILs showed a better overall survival, although not statistically significant for either parameters. The gene discussed is GZMB; the disease is familial adenomatous polyposis 2.