The median number of CD8+ lymphocytes in MAP CRCs, scored with IHC, fell somewhere between that found in MSI-stable and MSI-high CRC's (indicated by absent MLH-1 expression) previously analyzed with the same procedure in our laboratory.[34] O'Shea et al. reported the same percentage of TILs present in MAP CRCs as in their controls (50%, 8/16).[31] Their controls, however, might not be representative of sporadic CRCs, as the number of TILs reported by others in sporadic CRCs is much less (24%, Table 2 and 3). The gene discussed is MLH1; the disease is colorectal carcinoma.